Ser61
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Home > Phosphorylation Site Page: > Ser61  -  BID (mouse)

Site Information
DELQtDGsQAsRsFN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448404

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , electrophoretic mobility shift ( 2 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 , 2 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 2 , 3 ) , MEF (fibroblast) [IGF1R (mouse)] ( 1 )

Upstream Regulation
Kinases, in vitro:
CK1A (human) ( 3 )
Treatments:
aphidicolin ( 1 ) , etoposide ( 1 , 2 ) , hydroxyurea ( 1 ) , ionizing_radiation ( 2 ) , LY294002 ( 1 ) , mitomycin_C ( 1 ) , wortmannin ( 1 )

Downstream Regulation
Effects of modification on BID:
protein stabilization ( 3 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 , 3 ) , cell cycle regulation ( 2 )

References 

1

Zinkel SS, et al. (2005) A role for proapoptotic BID in the DNA-damage response. Cell 122, 579-91
16122425   Curated Info

2

Kamer I, et al. (2005) Proapoptotic BID is an ATM effector in the DNA-damage response. Cell 122, 593-603
16122426   Curated Info

3

Desagher S, et al. (2001) Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8. Mol Cell 8, 601-11
11583622   Curated Info

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