Ser46
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Home > Phosphorylation Site Page: > Ser46  -  fumarase (human)

Site Information
PNAARMAsQNSFRIE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 36132325

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 ) , non-small cell squamous cell lung carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PAK4 (human) ( 1 )
Kinases, in vitro:
PAK4 (human) ( 1 )
Treatments:
PF-03758309 ( 1 )

Downstream Regulation
Effects of modification on fumarase:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , signaling pathway regulation ( 1 )
Induce interaction with:
14-3-3 zeta (human) ( 1 )
Inhibit interaction with:
RBPJ (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
non-small cell lung cancer ( 1 )

References 

1

Jiang Y, et al. (2019) PAK4 phosphorylates fumarase and blocks TGF-β-induced cell growth arrest in lung cancer cells. Cancer Res
30683654   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info