Ser291
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.5
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser291  -  cGAS (mouse)

Site Information
VEKEKPGsPAVTLLI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 36128853

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 1 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
fibrosarcoma of soft tissue ( 1 , 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 2 ) , HT1080 (fibroblast) ( 1 ) , L929 (fibroblast) ( 1 , 2 ) , RAW 264.7 (macrophage) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 2 ) , CDK1 (human) ( 1 )
Kinases, in vitro:
Akt1 (human) ( 2 )
Treatments:
Akt_inhibitor_VIII ( 1 ) , calyculin_A ( 1 ) , Cdk2_inhibitor_II ( 1 ) , nocodazole ( 1 ) , okadaic_acid ( 1 ) , RO-3306 ( 1 )

Downstream Regulation
Effects of modification on cGAS:
enzymatic activity, inhibited ( 2 )

References 

1

Zhong L, et al. (2020) Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis. Cell Discov 6, 26
32351706   Curated Info

2

Seo GJ, et al. (2015) Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway. Cell Rep 13, 440-9
26440888   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2024 Cell Signaling Technology, Inc.