Ser305
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Home > Phosphorylation Site Page: > Ser305  -  cGAS (human)

Site Information
MKRkRGGsPAVTLLI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 36128853

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 , 3 ) , mass spectrometry ( 1 , 4 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
fibrosarcoma of soft tissue ( 2 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , HEK293T (epithelial) ( 1 , 3 ) , HeLa (cervical) ( 4 ) , HFF1 (fibroblast) ( 1 ) , HT1080 (fibroblast) ( 2 ) , L929 (fibroblast) ( 3 )

Upstream Regulation
Kinases, in vitro:
CDK1 (human) ( 2 )
Treatments:
nocodazole ( 2 ) , taxol ( 2 )

Downstream Regulation
Effects of modification on cGAS:
enzymatic activity, inhibited ( 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 )

References 

1

Song B, et al. (2020) The DNA sensor cGAS is decorated by acetylation and phosphorylation modifications in the context of immune signaling. Mol Cell Proteomics
32345711   Curated Info

2

Zhong L, et al. (2020) Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis. Cell Discov 6, 26
32351706   Curated Info

3

Seo GJ, et al. (2015) Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway. Cell Rep 13, 440-9
26440888   Curated Info

4

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

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