Thr19
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Home > Phosphorylation Site Page: > Thr19  -  PSD-95 (rat)

Site Information
YRYQDEDtPPLEHSP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3609101

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'neuron, hippocampal, CA1 pyramidal'-brain ( 1 ) , 293 (epithelial) ( 1 ) , COS7 (fibroblast) ( 1 ) , neuron-'brain, hippocampus' ( 1 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 1 )
Kinases, in vitro:
GSK3B (rat) ( 1 )
Treatments:
gly-aCSF ( 1 ) , lithium ( 1 ) , NMDA ( 1 ) , SB216763 ( 1 ) , seliciclib ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on PSD-95:
intracellular localization ( 1 ) , protein degradation ( 1 ) , receptor internalization, induced ( 1 )
Effects of modification on biological processes:
neural plasticity ( 1 )

References 

1

Nelson CD, et al. (2013) Phosphorylation of Threonine-19 of PSD-95 by GSK-3β is Required for PSD-95 Mobilization and Long-Term Depression. J Neurosci 33, 12122-35
23864697   Curated Info