Tyr992
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Home > Phosphorylation Site Page: > Tyr992  -  TIE2 (human)

Site Information
LSRGQEVyVKKtMGR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448373

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
EPCR (human) ( 2 ) , F10 (human) ( 2 ) , PAR3 (human) ( 2 )
Kinases, in vitro:
TIE2 (human) ( 3 , 4 )
Treatments:
angiopoietin-1 ( 1 )

Downstream Regulation
Effects of modification on TIE2:
activity, induced ( 2 ) , protein conformation ( 1 )

References 

1

Leppänen VM, Saharinen P, Alitalo K (2017) Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization. Proc Natl Acad Sci U S A 114, 4376-4381
28396439   Curated Info

2

Stavenuiter F, Mosnier LO (2014) Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity. Blood 124, 3480-9
25320242   Curated Info

3

Murray BW, Padrique ES, Pinko C, McTigue MA (2001) Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2. Biochemistry 40, 10243-53
11513602   Curated Info

4

Shewchuk LM, et al. (2000) Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail. Structure 8, 1105-13
11080633   Curated Info