Tyr1108
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Home > Phosphorylation Site Page: > Tyr1108  -  TIE2 (human)

Site Information
TyVNTTLyEKFTyAG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448372

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
TIE2 (human) ( 4 )

Downstream Regulation
Effects of modification on TIE2:
enzymatic activity, induced ( 2 )

References 

1

Zhou J (2010) CST Curation Set: 9107; Year: 2010; Biosample/Treatment: cell line, NTERA-2/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-102) Cat#: 9416
Curated Info

2

Sturk C, Dumont DJ (2010) Tyrosine phosphorylation of Grb14 by Tie2. Cell Commun Signal 8, 30
20973951   Curated Info

3

Audero E, et al. (2004) Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells. J Biol Chem 279, 13224-33
14665640   Curated Info

4

Murray BW, Padrique ES, Pinko C, McTigue MA (2001) Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2. Biochemistry 40, 10243-53
11513602   Curated Info