Ser664
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Home > Phosphorylation Site Page: > Ser664  -  5-LO (human)

Site Information
QLPYYYLsPDRIPNs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 461913

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mass spectrometry ( 3 ) , mass spectrometry (in vitro) ( 3 ) , mutation of modification site ( 4 , 5 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
leukemia ( 2 , 3 ) , acute myelogenous leukemia ( 2 , 3 ) , lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
Calu 6 (pulmonary) ( 1 ) , HeLa (cervical) ( 4 , 5 ) , Mono Mac 6 (myeloid) ( 3 ) , THP1 (myeloid) ( 2 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 2 )
Kinases, in vitro:
ERK2 (human) ( 5 )
Treatments:
apocynin ( 1 ) , arachidonic_acid ( 5 ) , Daidzin ( 2 ) , linoleic_acid ( 5 ) , oleic_acid ( 5 ) , PD98059 ( 1 , 2 ) , U0126 ( 2 ) , WKYMVm ( 1 ) , WRW4 ( 1 )

Downstream Regulation
Effects of modification on 5-LO:
enzymatic activity, induced ( 2 , 4 )

References 

1

Pecchillo Cimmino T, et al. (2024) Formyl Peptide Receptor 2-Dependent cPLA2 and 5-LOX Activation Requires a Functional NADPH Oxidase. Antioxidants (Basel) 13
38397818   Curated Info

2

Horio Y, Isegawa Y, Shichiri M (2023) Daidzein phosphorylates and activates 5-lipoxygenase via the MEK/ERK pathway: a mechanism for inducing the production of 5-lipoxygenase metabolite that inhibit influenza virus intracellular replication. J Nutr Biochem 114, 109276
36682398   Curated Info

3

Markoutsa S, et al. (2014) Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS. FEBS J 281, 1931-47
24860872   Curated Info

4

Fischer L, et al. (2003) Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors. FASEB J 17, 949-51
12670876   Curated Info

5

Werz O, et al. (2002) Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes. FASEB J 16, 1441-3
12205041   Curated Info

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