Ser374
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Home > Phosphorylation Site Page: > Ser374  -  NRF2 (human)

Site Information
GDtLLGLsDsEVEEL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 35497700

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AMPKA1 (human) ( 1 , 2 )
Kinases, in vitro:
AMPKA1 (human) ( 2 )
Treatments:
A-769662 ( 1 , 2 ) , compound_C ( 2 ) , MG132 ( 2 )

Downstream Regulation
Effects of modification on NRF2:
activity, induced ( 2 ) , molecular association, regulation ( 1 , 2 ) , protein degradation ( 1 ) , protein stabilization ( 2 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 2 ) , transcription, induced ( 2 ) , transcription, inhibited ( 1 )
Induce interaction with:
BTRC (human) ( 2 ) , FBW1B (human) ( 1 )

References 

1

Petsouki E, Ender S, Sosa Cabrera SN, Heiss EH (2023) AMPK-Mediated Phosphorylation of Nrf2 at S374/S408/S433 Favors Its ╬▓TrCP2-Mediated Degradation in KEAP1-Deficient Cells. Antioxidants (Basel) 12
37627580   Curated Info

2

Matzinger M, et al. (2020) AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes. Redox Biol 29, 101393
31805502   Curated Info