Ser2516
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser2516  -  Notch 1 (human)

Site Information
FLtPsPEsPDQWsss   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 35483202

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
MEF (fibroblast) ( 1 ) , SF9 ( 1 ) , T-ALL (T lymphocyte) ( 1 ) , thymocyte ( 1 )

Upstream Regulation
Putative in vivo kinases:
CDK19 (human) ( 1 ) , CDK3 (human) ( 1 ) , CDK8 (human) ( 1 )

Downstream Regulation
Effects of modification on Notch 1:
molecular association, regulation ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 )
Induce interaction with:
FBXW7 (human) ( 1 )

References 

1

Li N, et al. (2014) Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol 16, 1080-91
25344755   Curated Info