Ser719
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Home > Phosphorylation Site Page: > Ser719  -  NHE3 (rabbit)

Site Information
KERELELsDPEEAPD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3496800

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CK2A1 (human) ( 2 )
Kinases, in vitro:
CK2A1 (human) ( 1 , 2 ) , CK2B (human) ( 1 )
Treatments:
DMAT ( 2 ) , TBB ( 2 )

Downstream Regulation
Effects of modification on NHE3:
activity, induced ( 2 ) , activity, inhibited ( 1 ) , intracellular localization ( 2 ) , molecular association, regulation ( 1 )
Induce interaction with:
SNX27 (human) ( 1 )

References 

1

Sarker R, et al. (2017) Phosphorylation of NHE3-S(719) regulates NHE3 activity through the formation of multiple signaling complexes. Mol Biol Cell 28, 1754-1767
28495796   Curated Info

2

Sarker R, et al. (2008) Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3. Mol Biol Cell 19, 3859-70
18614797   Curated Info