Ser192
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Home > Phosphorylation Site Page: > Ser192  -  TAK1 (human)

Site Information
HMtNNKGsAAWMAPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448289

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , E.coli (bacterial) ( 2 ) , HeLa (cervical) ( 3 ) , NCM460 (epithelial) ( 1 )

Upstream Regulation
Regulatory protein:
Bcl-10 (human) ( 1 )
Putative in vivo kinases:
TAK1 (human) ( 2 )
Treatments:
carrageenan ( 1 )

Downstream Regulation
Effects of modification on TAK1:
enzymatic activity, induced ( 2 , 3 ) , phosphorylation ( 3 )

References 

1

Bhattacharyya S, et al. (2011) Specific effects of BCL10 Serine mutations on phosphorylations in canonical and noncanonical pathways of NF-{kappa}B activation following carrageenan. Am J Physiol Gastrointest Liver Physiol 301, G475-86
21700900   Curated Info

2

Scholz R, et al. (2010) Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process. J Biol Chem 285, 25753-66
20538596   Curated Info

3

Singhirunnusorn P, et al. (2005) Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. J Biol Chem 280, 7359-68
15590691   Curated Info