Tyr470
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Home > Phosphorylation Site Page: > Tyr470  -  TGFBR2 (human)

Site Information
AVGEVKDyEPPFGSk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 34729902

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , kidney ( 1 )

Upstream Regulation
Regulatory protein:
ITGA1 (human) ( 1 )
Phosphatases, in vitro:
PTPN2 (human) ( 1 )

Downstream Regulation
Effects of modification on TGFBR2:
activity, induced ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 )

References 

1

Chen X, et al. (2014) Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest 124, 3295-310
24983314   Curated Info