Ser465
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Home > Phosphorylation Site Page: > Ser465  -  PARP1 (human)

Site Information
FLQDVSAsTkSLQEL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 34729900

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry (in vitro) ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lymphoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 )
Kinases, in vitro:
PKACA (human) ( 1 )
Treatments:
cAMP_analog ( 1 ) , H2O2 ( 1 ) , PKI-(14-22)amide ( 1 ) , propranolol ( 1 )

Downstream Regulation
Effects of modification on PARP1:
enzymatic activity, induced ( 1 )

References 

1

Brunyanszki A, et al. (2014) Regulation of Mitochondrial Poly(ADP-Ribose) Polymerase Activation by the β-Adrenoceptor/cAMP/Protein Kinase A Axis during Oxidative Stress. Mol Pharmacol 86, 450-62
25069723   Curated Info