Lys273

Site Information
EEkRVNSkFDtIyQI SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 461311
Available spectra: 1 CST

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 )
Disease tissue studied:	gastric cancer ( 2 ) , leukemia ( 9 ) , lung cancer ( 7 ) , non-small cell lung cancer ( 3 , 7 )
Relevant cell line - cell type - tissue:	A549 (pulmonary) ( 4 ) , HeLa (cervical) ( 1 ) , Jurkat (T lymphocyte) ( 4 ) , MKN-45 (gastric) ( 2 ) , MV4-11 (macrophage) ( 4 ) , NCI-H23 (pulmonary) ( 7 , 8 ) , NCI-H3255 (pulmonary) ( 3 , 5 ) , NCI-H520 (squamous) ( 6 ) , OCI/AML3 (myeloid) ( 9 )

References
1	Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51 23954790 Curated Info
2	Rikova K (2012) CST Curation Set: 16030; Year: 2012; Biosample/Treatment: cell line, MKN45/crizotinib; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Curated Info
3	Rikova K (2012) CST Curation Set: 16031; Year: 2012; Biosample/Treatment: cell line, H3255/iressa; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Curated Info
4	Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325, 834-40 19608861 Curated Info
5	Guo A (2006) CST Curation Set: 1209; Year: 2006; Biosample/Treatment: cell line, NCI-H3255/-; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine Antibody Cat#: 9441 Curated Info
6	Mitchell J (2006) CST Curation Set: 1210; Year: 2006; Biosample/Treatment: cell line, NCI-H520/serum starved; Disease: non-small cell squamous cell lung carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine Antibody Cat#: 9441 Curated Info
7	Mitchell J (2006) CST Curation Set: 1212; Year: 2006; Biosample/Treatment: cell line, NCI-H23/serum starved; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine Antibody Cat#: 9441 Curated Info
8	Mitchell J (2006) CST Curation Set: 1213; Year: 2006; Biosample/Treatment: cell line, NCI-H23/serum starved; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine Antibody Cat#: 9441 Curated Info
9	Gu T (2005) CST Curation Set: 1006; Year: 2005; Biosample/Treatment: cell line, OCI/AML3/-; Disease: acute myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine Antibody Cat#: 9441 Curated Info