Ser35

Site Information
QALPREQsPPPPLQT SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 34501609

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 )
Disease tissue studied:	HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) [DGCR8 (human), transfection] ( 3 ) , breast ( 1 ) , liver ( 2 )

Downstream Regulation
Effects of modification on DGCR8:	protein stabilization ( 3 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62 24275569 Curated Info
3	Herbert KM, et al. (2013) Phosphorylation of DGCR8 increases its intracellular stability and induces a progrowth miRNA profile. Cell Rep 5, 1070-81 24239349 Curated Info