Ser96
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Home > Phosphorylation Site Page: > Ser96  -  HRC (human)

Site Information
EKEDEDVsKEyGHLL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 34499322

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 3 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
bone cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
FAM20C (mouse) ( 2 )
Kinases, in vitro:
FAM20C (human) ( 2 )

Downstream Regulation
Effects of modification on HRC:
molecular association, regulation ( 2 )
Induce interaction with:
SERCA2 (human) ( 2 ) , TRDN (human) ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
atrial fibrillation ( 1 )

References 

1

Amioka M, et al. (2019) Ser96Ala genetic variant of the human histidine-rich calcium-binding protein is a genetic predictor of recurrence after catheter ablation in patients with paroxysmal atrial fibrillation. PLoS One 14, e0213208
30840693   Curated Info

2

Pollak AJ, et al. (2017) Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia. Proc Natl Acad Sci U S A 114, 9098-9103
28784772   Curated Info

3

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info