Ser153
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Home > Phosphorylation Site Page: > Ser153  -  DGCR8 (human)

Site Information
AECGLLLsPVSGDVH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 34490414

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:
HCT116 (intestinal) ( 1 ) , HeLa (cervical) ( 2 )

Upstream Regulation
Regulatory protein:
CDK9 (human) ( 1 )
Putative in vivo kinases:
JNK1 (human) ( 1 )
Kinases, in vitro:
JNK1 (human) ( 1 )
Treatments:
UV ( 1 ) , UVB ( 1 )

Downstream Regulation
Effects of modification on biological processes:
DNA repair, inhibited ( 1 )

References 

1

Calses PC, et al. (2017) DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing. Cell Rep 19, 162-174
28380355   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

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