Ser1333

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Home > Phosphorylation Site Page: > Ser1333 - ATR (human)

Site Information
ETVEPIIsQLVTVLL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 34425600

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 )
Disease tissue studied:	colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:	HCT116 (intestinal) ( 1 ) , HEK293T (epithelial) ( 1 )

Downstream Regulation
Effects of modification on ATR:	enzymatic activity, induced ( 1 )
Effects of modification on biological processes:	cell cycle regulation ( 1 )

References
1	Luzwick JW, Nam EA, Zhao R, Cortez D (2014) Mutation of Serine 1333 in the ATR HEAT Repeats Creates a Hyperactive Kinase. PLoS One 9, e99397 24901225 Curated Info

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