Thr457
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Home > Phosphorylation Site Page: > Thr457  -  CEACAM1 (human)

Site Information
CFLHFGKtGRAsDQR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3439801

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 )
Disease tissue studied:
breast cancer ( 2 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on CEACAM1:
activity, inhibited ( 2 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
apoptosis, altered ( 2 )
Inhibit interaction with:
Calmodulin (human) ( 1 )

References 

1

Ghazarian H, et al. (2019) NMR analysis of free and lipid nanodisc anchored CEACAM1 membrane proximal peptides with Ca/CaM. Biochim Biophys Acta Biomembr 1861, 787-797
30639287   Curated Info

2

Li C, Chen CJ, Shively JE (2009) Mutational analysis of the cytoplasmic domain of CEACAM1-4L in humanized mammary glands reveals key residues involved in lumen formation: stimulation by Thr-457 and inhibition by Ser-461. Exp Cell Res 315, 1225-33
19146852   Curated Info