Tyr1176
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Home > Phosphorylation Site Page: > Tyr1176  -  CTNND2 (mouse)

Site Information
QEPSRkDyETyQPFP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 461085

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
prostate cancer ( 1 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 1 ) , BOSC ( 1 ) , CWR22Rv1 (prostate cell) ( 1 ) , MEF (fibroblast) ( 1 , 2 ) , MEF (fibroblast) [PTP1B (mouse), homozygous knockout] ( 2 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 1 )
Treatments:
siRNA ( 1 ) , SU6656 ( 1 )

Downstream Regulation
Effects of modification on CTNND2:
molecular association, regulation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 2 ) , cell motility, altered ( 2 )
Inhibit interaction with:
GSK3B (human) ( 1 )

References 

1

He Y, et al. (2014) C-Src-mediated phosphorylation of δ-catenin increases its protein stability and the ability of inducing nuclear distribution of β-catenin. Biochim Biophys Acta 1843, 758-68
24412473   Curated Info

2

Mertins P, et al. (2008) Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics 7, 1763-77
18515860   Curated Info

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