Tyr1070
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Home > Phosphorylation Site Page: > Tyr1070  -  NMDAR2B (mouse)

Site Information
IsTHtVTyGNIEGNA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 461055
Associated spectra:  2 CST

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 3 , 4 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , brain ( 3 , 4 ) , neuron:postsynaptic density-'brain, hippocampus, CA1 region' ( 1 ) , neuron:synaptosome-'brain, cerebral cortex' ( 2 )

Upstream Regulation
Putative in vivo kinases:
FRK (mouse) ( 2 )
Kinases, in vitro:
Fyn (human) ( 2 )
Treatments:
long-term_potentiation ( 1 )

Downstream Regulation
Effects of modification on NMDAR2B:
molecular association, regulation ( 2 ) , phosphorylation ( 2 )
Induce interaction with:
Fyn (mouse) ( 2 )

References 

1

Li J, et al. (2016) Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Sci Signal 9, rs8
27507650   Curated Info

2

Lu W, et al. (2015) Phosphorylation of Tyrosine 1070 at the GluN2B Subunit Is Regulated by Synaptic Activity and Critical for Surface Expression of N-Methyl-d-aspartate (NMDA) Receptors. J Biol Chem 290, 22945-54
26229100   Curated Info

3

Guo A (2007) CST Curation Set: 3121; Year: 2007; Biosample/Treatment: tissue, brain/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y)p[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) PDK1 Docking Motif (18A2) Mouse mAb Cat#: 9634, PTMScan(R) Phospho-PDK1 Docking Motif (F/YS*/T*F/Y) Immunoaffinity Beads Cat#: 1992
Curated Info

4

Guo A (2007) CST Curation Set: 2675; Year: 2007; Biosample/Treatment: tissue, brain/LY; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info