Lys288

Site Information
CAHPGCGkSYTKSSH SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 461016

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Disease tissue studied:	leukemia ( 2 ) , chronic myelogenous leukemia ( 2 )
Relevant cell line - cell type - tissue:	18SCF (hepatocyte) ( 1 ) , COS7 (fibroblast) ( 2 ) , HEK293T (epithelial) ( 1 ) , K562 (erythroid) ( 2 ) , MEL (erythroid) ( 1 , 2 )

Downstream Regulation
Effects of modification on KLF1:	acetylation ( 1 ) , molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:	chromatin organization, altered ( 1 ) , transcription, induced ( 1 )
Induce interaction with:	DNA ( 1 )

References
1	Sengupta T, Chen K, Milot E, Bieker JJ (2008) Acetylation of EKLF is essential for epigenetic modification and transcriptional activation of the beta-globin locus. Mol Cell Biol 28, 6160-70 18710946 Curated Info
2	Zhang W, Kadam S, Emerson BM, Bieker JJ (2001) Site-specific acetylation by p300 or CREB binding protein regulates erythroid Krüppel-like factor transcriptional activity via its interaction with the SWI-SNF complex. Mol Cell Biol 21, 2413-22 11259590 Curated Info