Ser319
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Home > Phosphorylation Site Page: > Ser319  -  PSEN1 (human)

Site Information
NskyNAEstEREsQD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3397301

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
T20 (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
JNK2 (human) ( 1 )
Kinases, in vitro:
JNK2 (human) ( 1 )
Treatments:
SP600125 ( 1 ) , TNF ( 1 )

Downstream Regulation
Effects of modification on PSEN1:
enzymatic activity, induced ( 1 ) , protein stabilization ( 1 )

References 

1

Kuo LH, et al. (2008) Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin. Mol Biol Cell 19, 4201-12
18667537   Curated Info

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