Ser133
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Site Information
EILsRRPsYRkILND   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448228

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 79 , 81 ) , [32P] bio-synthetic labeling ( 67 , 73 , 81 , 82 ) , electrophoretic mobility shift ( 41 , 73 ) , immunoprecipitation ( 82 ) , mass spectrometry ( 4 , 17 ) , mutation of modification site ( 23 , 31 , 38 , 42 , 48 , 52 , 54 , 57 , 58 , 59 , 62 , 67 , 69 , 79 ) , phospho-antibody ( 3 , 4 , 5 , 6 , 7 , 8 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 18 , 19 , 20 , 22 , 23 , 24 , 25 , 26 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 60 , 61 , 62 , 63 , 64 , 66 , 68 , 69 , 70 , 72 , 75 , 76 , 80 , 81 ) , phosphopeptide mapping ( 79 , 81 , 82 ) , western blotting ( 3 , 4 , 6 , 7 , 9 , 10 , 12 , 14 , 15 , 16 , 19 , 20 , 22 , 24 , 25 , 26 , 28 , 29 , 30 , 31 , 32 , 33 , 35 , 36 , 39 , 40 , 42 , 43 , 44 , 46 , 47 , 48 , 49 , 50 , 52 , 54 , 55 , 59 , 62 , 63 , 64 , 68 , 70 , 79 )
Disease tissue studied:
adrenal cancer ( 6 , 17 , 22 , 23 , 44 , 47 , 64 , 68 ) , pheochromocytoma ( 6 , 17 , 22 , 23 , 44 , 47 , 64 , 68 ) , bone cancer ( 12 , 40 , 48 , 52 ) , brain cancer ( 40 ) , glioma ( 40 ) , lymphoma ( 59 ) , T cell lymphoma ( 59 ) , neuroblastoma ( 58 ) , pancreatic cancer ( 9 , 25 ) , pancreatic carcinoma ( 9 , 25 )
Relevant cell line - cell type - tissue:
'brain, amygdala' ( 18 ) , 'brain, caudate-putamen' ( 18 ) , 'brain, cerebral cortex' ( 5 , 16 , 18 ) , 'brain, hippocampus' ( 10 , 18 , 61 ) , 'brain, hippocampus, dentate gyrus' ( 19 , 42 ) , 'brain, nucleus accumbens' ( 18 ) , 'brain, striatum' ( 16 ) , 'brain, ventral tegmental area' ( 18 ) , 'neuron, bipolar' ( 39 ) , 'neuron, cerebellar granule'-brain ( 66 ) , 'neuron, cortical' ( 11 ) , 'neuron, cortical'-brain ( 15 , 20 , 29 , 34 , 35 , 51 , 53 ) , 'neuron, hippocampal'-brain ( 15 , 43 , 46 ) , 'neuron, striatal' ( 13 ) , 'neuron, suprachiasmatic nucleus'-brain ( 80 ) , 12-1 ( 26 ) , adipocyte-adipose tissue ( 4 ) , adipose tissue ( 28 ) , adrenal gland ( 3 ) , astrocyte-'brain, striatum' ( 72 ) , bacterial ( 62 ) , C6 (glial) ( 40 ) , COS (fibroblast) ( 73 ) , CV1 (fibroblast) ( 58 ) , DP5-2 ( 26 ) , EL-4 (T lymphocyte) ( 59 ) , GH3 (epithelial) ( 79 ) , granulosa ( 30 , 55 ) , H19-7 (neuron) [IGF1R (human)] ( 38 , 57 ) , H4IIe (hepatic) ( 69 ) , HEK293T (epithelial) ( 23 , 67 ) , HiB5 (neuron) ( 56 ) , HIT-T15 (pancreatic) ( 75 , 76 ) , INS-1 (pancreatic) ( 9 , 25 ) , L6 (myoblast) ( 72 ) , mesangial ( 31 ) , myocyte-heart ( 36 ) , neuron-'brain, cerebral cortex' ( 7 ) , neuron-'brain, hippocampus' ( 8 , 14 , 63 ) , neuron-'brain, hypothalamus' ( 49 ) , neuron-spinal cord ( 33 ) , PC-12 (chromaffin) ( 6 , 17 , 22 , 23 , 41 , 44 , 45 , 47 , 60 , 64 , 68 , 70 , 73 , 81 ) , Schwann ( 24 ) , sertoli-testis ( 37 ) , SK-N-MC (neural crest) ( 58 ) , UMR106 (bone cell) ( 12 , 40 , 48 , 52 ) , vascular smooth muscle cell ('muscle, smooth') ( 32 , 54 ) , VSMC-aorta ( 50 )

Upstream Regulation
Regulatory protein:
AKAP5 (human) ( 14 ) , CACNA1D (rat) ( 34 ) , PKCA (rat) ( 21 ) , PKCD (rat) ( 21 ) , PKCE (rat) ( 21 , 22 ) , PRKD1 (rat) ( 21 ) , Rab7 (rat) ( 33 )
Putative in vivo kinases:
Akt1 (human) ( 67 ) , Btk (human) ( 38 ) , CAMK2A (mouse) ( 62 , 79 ) , CAMK4 (mouse) ( 62 , 79 ) , PKACA (rat) ( 26 , 46 , 62 , 69 ) , RSK2 (human) ( 73 ) , SGK1 (human) ( 23 )
Kinases, in vitro:
Akt1 (human) ( 67 ) , CAMK1A (rat) ( 82 ) , CAMK2A (human) ( 58 ) , CAMK2A (mouse) ( 79 ) , CAMK2A (rat) ( 82 ) , CAMK4 (mouse) ( 79 ) , GSK3A (rat) ( 52 ) , MAPKAPK2 (human) ( 70 ) , MSK1 (human) ( 68 ) , p90RSK (rat) ( 68 ) , PKACA (human) ( 27 , 51 , 52 , 58 , 71 , 79 ) , PKACA (rat) ( 78 , 82 ) , SGK1 (human) ( 23 )
Phosphatases, in vitro:
PPP1CA (human) ( 27 )
Treatments:
1-methoxyoctadecan-1-ol ( 7 ) , 4-AP ( 35 ) , 8-Rp-cAMP ( 35 , 36 ) , A23187 ( 40 , 50 ) , ACTH ( 3 ) , AG1478 ( 21 , 50 , 54 ) , AG825 ( 24 ) , angiotensin_2 ( 50 ) , anti-CD28 ( 59 ) , anti-CD3 ( 59 ) , anti-CD3/CD28 ( 59 ) , antisauvagine-30 ( 13 ) , APV ( 35 , 42 , 63 ) , AR-A014418 ( 16 ) , astressin ( 13 ) , BAPTA-AM ( 13 ) , BDNF ( 14 , 16 , 33 , 39 , 51 ) , beta-amyloid_42 ( 46 ) , bicuculline ( 35 , 43 , 49 ) , bisindolylmaleimide ( 22 , 35 ) , calphostin_C ( 57 ) , cAMP_analog ( 44 , 51 , 69 ) , cGMP_analog ( 40 ) , CGS_21680 ( 47 ) , chelerythrine ( 57 ) , cholera_toxin ( 6 , 13 ) , ciclosporin ( 20 , 63 , 76 ) , CNQX ( 35 ) , cobalt ( 22 ) , colforsin ( 13 , 14 , 24 , 25 , 36 , 45 , 49 , 50 , 56 , 63 , 68 , 76 , 81 ) , CP154526 ( 13 ) , CRF ( 13 ) , culturing_of_cells ( 29 ) , CV11974 ( 50 ) , deoxygenation ( 11 ) , depolarization ( 13 , 14 , 15 , 20 , 34 , 49 , 51 , 56 , 75 , 76 , 82 ) , desipramine ( 75 ) , DRB ( 57 ) , EGF ( 21 , 48 , 57 , 68 , 73 ) , electrical_stimulation ( 42 ) , ephrin_B2 ( 53 ) , estradiol ( 57 ) , exercise ( 61 ) , FGF1 ( 57 ) , FGF2 ( 38 ) , FK506 ( 11 , 35 , 63 , 76 ) , FR167653 ( 54 ) , GABA ( 49 ) , gallein ( 13 ) , genistein ( 52 ) , GF109203X ( 21 , 50 ) , GIP ( 25 ) , glutamic acid ( 7 , 46 , 51 , 53 ) , glycine ( 43 ) , Go_6976 ( 21 ) , H-89 ( 4 , 6 , 13 , 14 , 25 , 26 , 35 , 36 , 47 , 48 , 50 ) , H2O2 ( 21 ) , HDBA ( 57 ) , heparin sodium ( 57 ) , herbimycin_A ( 57 ) , heroin_withdrawal ( 18 ) , histamine ( 14 ) , hypoxia ( 60 , 64 ) , IGF-1 ( 31 , 34 ) , IGF-2 ( 10 ) , insulin ( 48 , 50 , 69 ) , ischemia ( 66 ) , ischemia/reperfusion ( 19 , 66 ) , isoproterenol ( 13 , 21 ) , JNK_inhibitor_VIII ( 6 ) , K252a ( 57 ) , KCl ( 63 ) , KN-62 ( 14 , 35 , 40 , 51 , 57 , 59 ) , KN-93 ( 13 , 50 , 64 ) , KT5720 ( 57 ) , lactoferrin ( 4 ) , laminin-1 ( 24 ) , learning ( 10 , 23 ) , light ( 80 ) , lithium ( 52 ) , long-term_potentiation ( 42 ) , LY294002 ( 57 ) , m119 ( 13 ) , memantine ( 5 ) , metribolone ( 37 ) , MG132 ( 43 ) , muscimol ( 49 ) , NAC ( 22 ) , neuregulin ( 24 ) , NGF ( 45 , 47 , 68 , 70 ) , nifedipine ( 13 ) , nimodipine ( 14 , 63 ) , NKH_477 ( 9 ) , NMDA ( 35 , 63 ) , norepinephrine ( 21 ) , okadaic_acid ( 63 ) , osmotic_stress ( 6 ) , PAR1-activating_peptide ( 54 ) , Pasteurella_multocida_toxin ( 21 ) , PCP ( 16 ) , PD90059 ( 59 ) , PD98059 ( 22 , 26 , 32 , 42 , 47 , 48 , 50 , 51 , 54 , 57 , 59 , 68 , 70 ) , PDGF ( 32 ) , peptide inhibitor ( 14 ) , phenylephrine ( 36 ) , phorbol_ester ( 21 , 50 , 73 ) , PKI-(14-22)amide ( 24 , 30 ) , prazosin ( 21 , 36 ) , propranolol ( 21 , 36 ) , PTH ( 12 , 48 , 52 ) , PTX ( 13 ) , PTZ ( 51 ) , rapamycin ( 30 , 57 ) , Ro31-8220 ( 36 , 57 , 68 ) , rolipram ( 46 ) , SB203580 ( 26 , 36 , 48 , 50 , 54 , 57 , 59 , 68 , 70 ) , SB216763 ( 31 ) , serum ( 67 ) , SH-5 ( 31 ) , siRNA ( 22 ) , SQ22536 ( 13 ) , staurosporine ( 11 ) , SU6656 ( 19 ) , testosterone ( 37 ) , TeTx ( 39 ) , TGF-beta ( 30 ) , thrombin ( 21 , 54 ) , TNF ( 68 ) , TTX ( 35 , 43 ) , tyrphostin_A47 ( 57 ) , U0126 ( 13 , 14 , 19 , 21 , 26 , 35 , 49 , 54 ) , urofollitropin ( 30 , 55 ) , UV ( 68 , 70 ) , W-7 ( 50 ) , wortmannin ( 30 , 50 , 60 )

Downstream Regulation
Effects of modification on CREB:
activity, induced ( 47 , 49 , 59 , 61 , 63 , 65 , 68 , 73 , 79 ) , intracellular localization ( 21 , 49 ) , molecular association, regulation ( 36 , 58 , 62 , 67 , 71 ) , protein conformation ( 27 , 65 )
Effects of modification on biological processes:
cell growth, altered ( 19 , 38 , 47 , 63 ) , signaling pathway regulation ( 9 ) , transcription, altered ( 21 , 38 , 59 , 65 , 67 , 73 ) , transcription, induced ( 3 , 36 , 48 , 52 , 54 , 57 , 58 , 72 , 79 )
Induce interaction with:
CBP (human) ( 58 , 67 ) , CBP (mouse) ( 59 , 62 , 65 , 71 ) , CBP (rat) ( 36 , 51 ) , CREM iso2 (mouse) ( 65 ) , DNA ( 27 )

References 

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Curated Info

18

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23

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24

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