Tyr1333
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Home > Phosphorylation Site Page: > Tyr1333  -  VEGFR1 (human)

Site Information
DyNSVVLySTPPI__   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448212

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 , 3 , 4 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 2 ) , MS1 (endothelial) ( 4 ) , PAE (endothelial) ( 3 ) , SF9 ( 2 )

Upstream Regulation
Kinases, in vitro:
VEGFR1 (human) ( 4 )

Downstream Regulation
Effects of modification on VEGFR1:
molecular association, regulation ( 2 , 4 ) , protein degradation ( 2 ) , receptor internalization, altered ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 3 ) , cell growth, altered ( 3 ) , signaling pathway regulation ( 1 )
Induce interaction with:
CBL (human) ( 2 ) , CRK (mouse) ( 4 ) , NCK1 (mouse) ( 4 ) , PLCG1 (mouse) ( 4 )

References 

1

Kanthou C, et al. (2014) Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics. PLoS One 9, e104015
25119572   Curated Info

2

Kobayashi S, et al. (2004) The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1). FASEB J 18, 929-31
15001553   Curated Info

3

Ito N, Huang K, Claesson-Welsh L (2001) Signal transduction by VEGF receptor-1 wild type and mutant proteins. Cell Signal 13, 849-54
11583921   Curated Info

4

Ito N, Wernstedt C, Engström U, Claesson-Welsh L (1998) Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules. J Biol Chem 273, 23410-8
9722576   Curated Info