Tyr1242
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Home > Phosphorylation Site Page: > Tyr1242  -  VEGFR1 (human)

Site Information
ATSMFDDyQGDSSTL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448210

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 2 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:
lung ( 1 ) , PAE (endothelial) ( 2 )

Upstream Regulation
Kinases, in vitro:
VEGFR1 (human) ( 3 )

Downstream Regulation
Effects of modification on biological processes:
cell cycle regulation ( 2 ) , cell growth, altered ( 2 )

References 

1

Guo A (2006) CST Curation Set: 1161; Year: 2006; Biosample/Treatment: tissue, lung/-; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

Ito N, Huang K, Claesson-Welsh L (2001) Signal transduction by VEGF receptor-1 wild type and mutant proteins. Cell Signal 13, 849-54
11583921   Curated Info

3

Ito N, Wernstedt C, Engström U, Claesson-Welsh L (1998) Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules. J Biol Chem 273, 23410-8
9722576   Curated Info