Ser14
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Home > Phosphorylation Site Page: > Ser14  -  Bcl-xL (mouse)

Site Information
ELVVDFLsYKLSQKG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 33668512

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 3 ) , immunoprecipitation ( 3 ) , mass spectrometry (in vitro) ( 1 , 3 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , heart ( 1 ) , heart [Bcl-xL (mouse), genetic knockin] ( 2 ) , myocyte-heart ( 3 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 1 ) , MST1 (human) ( 3 )
Kinases, in vitro:
ERK1 (human) ( 1 ) , MST1 (human) ( 3 )
Treatments:
H2O2 ( 3 ) , ischemia/reperfusion ( 2 , 3 ) , PD0325901 ( 1 ) , phenylephrine ( 1 ) , TAC ( 1 ) , triciribine ( 1 )

Downstream Regulation
Effects of modification on Bcl-xL:
intracellular localization ( 1 ) , molecular association, regulation ( 1 , 3 )
Effects of modification on biological processes:
apoptosis, induced ( 2 , 3 ) , signaling pathway regulation ( 1 , 3 ) , transcription, induced ( 1 )
Induce interaction with:
BID (human) ( 3 ) , BIM (human) ( 3 )
Inhibit interaction with:
BAX (human) ( 3 ) , IP3R1 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
cardiomyopathy ( 3 )

References 

1

Nakamura M, et al. (2023) Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice. Nat Commun 14, 5805
37726310   Curated Info

2

Nakamura M, et al. (2016) Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury. JCI Insight 1
27218122   Curated Info

3

Del Re DP, et al. (2014) Mst1 Promotes Cardiac Myocyte Apoptosis through Phosphorylation and Inhibition of Bcl-xL. Mol Cell 54, 639-50
24813943   Curated Info

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