Ser14
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser14  -  Bcl-xL (mouse)

Site Information
ELVVDFLsYKLSQKG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 33668512

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 2 ) , immunoprecipitation ( 2 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , heart [Bcl-xL (mouse), genetic knockin] ( 1 ) , myocyte-heart ( 2 )

Upstream Regulation
Putative in vivo kinases:
MST1 (human) ( 2 )
Kinases, in vitro:
MST1 (human) ( 2 )
Treatments:
H2O2 ( 2 ) , ischemia/reperfusion ( 1 , 2 )

Downstream Regulation
Effects of modification on Bcl-xL:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
apoptosis, induced ( 1 , 2 ) , signaling pathway regulation ( 2 )
Induce interaction with:
BID (human) ( 2 ) , BIM (human) ( 2 )
Inhibit interaction with:
BAX (human) ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
cardiomyopathy ( 2 )

References 

1

Nakamura M, et al. (2016) Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury. JCI Insight 1
27218122   Curated Info

2

Del Re DP, et al. (2014) Mst1 Promotes Cardiac Myocyte Apoptosis through Phosphorylation and Inhibition of Bcl-xL. Mol Cell 54, 639-50
24813943   Curated Info