Ser824
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Home > Phosphorylation Site Page: > Ser824  -  TIF1B (mouse)

Site Information
LPSAGLssQELSGPG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 460839

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 ) , mass spectrometry ( 4 , 5 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 , 3 , 6 , 7 ) , western blotting ( 2 , 3 , 7 )
Disease tissue studied:
anthrax infection ( 4 ) , bone cancer ( 3 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 ) , pancreatic ductal adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , 3T3 (fibroblast) ( 3 , 7 ) , B lymphocyte-spleen ( 6 ) , HEK293T (epithelial) ( 2 ) , MEF (fibroblast) ( 3 , 7 ) , mpkCCD (renal) ( 5 ) , NCI-H1299 (pulmonary) ( 3 ) , SL13 (fibroblast) ( 2 ) , spleen ( 4 ) , U2OS (bone cell) ( 3 )

Upstream Regulation
Regulatory protein:
ATM (mouse) ( 2 ) , ATR (mouse) ( 1 ) , HDAC1 (mouse) ( 7 ) , HDAC2 (mouse) ( 7 ) , HDAC3 (mouse) ( 7 ) , HP1 alpha (human) ( 3 )
Putative in vivo kinases:
ATM (mouse) ( 6 )
Treatments:
CPT ( 2 ) , ionizing_radiation ( 3 , 6 , 7 ) , KU-55933 ( 2 ) , neocarzinostatin ( 3 ) , olaparib ( 2 ) , siRNA ( 7 ) , triamcinolone_acetonide ( 3 )

Downstream Regulation
Effects of modification on TIF1B:
intracellular localization ( 3 )
Effects of modification on biological processes:
DNA repair, induced ( 3 )

References 

1

Perkhofer L, et al. (2017) ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage. Cancer Res 77, 5576-5590
28790064   Curated Info

2

Lee SS, et al. (2015) ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells. Cell Rep 13, 1623-32
26586427   Curated Info

3

White D, et al. (2012) The ATM substrate KAP1 controls DNA repair in heterochromatin: regulation by HP1 proteins and serine 473/824 phosphorylation. Mol Cancer Res 10, 401-14
22205726   Curated Info

4

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

5

Rinschen MM, et al. (2010) Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci U S A 107, 3882-7
20139300   Curated Info

6

Daniel JA, et al. (2008) Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J Cell Biol 183, 777-83
19047460   Curated Info

7

Bhaskara S, et al. (2008) Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell 30, 61-72
18406327   Curated Info