Ser63
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Home > Phosphorylation Site Page: > Ser63  -  SMN (human)

Site Information
NGDICETsGkPKttP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 33586274

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 )
Disease tissue studied:
chronic myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:
HAP1 ( 1 ) , HeLa (cervical) ( 2 ) , IMR-90 (fibroblast) ( 1 )

Upstream Regulation
Regulatory protein:
p70S6K (human) ( 1 )

Downstream Regulation
Effects of modification on SMN:
molecular association, regulation ( 1 ) , protein conformation ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 )
Induce interaction with:
SMN (human) ( 1 )

References 

1

Schilling M, et al. (2021) TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis. Cell Rep 35, 109277
34161763   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

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