Thr716
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Home > Phosphorylation Site Page: > Thr716  -  MAD1L1 (human)

Site Information
LELFSRQtVA_____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 334535800

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
TTK (human) ( 1 )
Kinases, in vitro:
TTK (human) ( 2 )
Treatments:
AZ3146 ( 1 ) , reversine ( 1 )

Downstream Regulation
Effects of modification on MAD1L1:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 1 , 2 )
Induce interaction with:
Mad2 (human) ( 2 )

References 

1

Allan LA, et al. (2020) Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint. EMBO J, e103180
32202322   Curated Info

2

Ji W, Luo Y, Ahmad E, Liu ST (2018) Direct interactions of mitotic arrest deficient 1 (MAD1) domains with each other and MAD2 conformers are required for mitotic checkpoint signaling. J Biol Chem 293, 484-496
29162720   Curated Info