Ser11
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Home > Phosphorylation Site Page: > Ser11  -  Myb (human)

Site Information
RPRHSIYssDEDDED   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448186

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , mutation of modification site ( 4 , 5 ) , phospho-antibody ( 4 ) , western blotting ( 4 )
Disease tissue studied:
adrenal cancer ( 5 ) , pheochromocytoma ( 5 ) , lymphoma ( 4 ) , anaplastic large cell lymphoma ( 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CK2A1 (human) ( 3 )

Downstream Regulation
Effects of modification on Myb:
molecular association, regulation ( 5 )
Effects of modification on biological processes:
transcription, altered ( 5 )
Inhibit interaction with:
DNA ( 5 )

References 

1

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

2

Possemato A (2009) CST Curation Set: 6911; Year: 2009; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info

3

Bergholtz S, et al. (2001) The highly conserved DNA-binding domains of A-, B- and c-Myb differ with respect to DNA-binding, phosphorylation and redox properties. Nucleic Acids Res 29, 3546-56
11522824   Curated Info

4

Cures A, et al. (2001) Constitutive c-Myb amino-terminal phosphorylation and DNA binding activity uncoupled during entry and passage through the cell cycle. Oncogene 20, 1784-92
11313925   Curated Info

5

Bousset K, et al. (1994) Regulation of transcription factors c-Myc, Max, and c-Myb by casein kinase II. Cell Mol Biol Res 40, 501-11
7735324   Curated Info