Ser1431

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Home > Phosphorylation Site Page: > Ser1431 - LRP6 (human)

Site Information
GYVPHPSsLSGSLPG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 460718

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , HEK293T (epithelial) ( 1 )

Upstream Regulation
Kinases, in vitro:	CK1E (human) ( 1 )

Downstream Regulation
Effects of modification on LRP6:	molecular association, regulation ( 1 )
Inhibit interaction with:	axin 1 (human) ( 1 )

References
1	Swiatek W, et al. (2006) Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation. J Biol Chem 281, 12233-41 16513652 Curated Info

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