Ser1420

Site Information
YVVHGPAsVPLGYVP SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 460717

In vivo Characterization
Methods used to characterize site in vivo:	immunoassay ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:	breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 2 ) , breast ( 1 ) , BT-549 (breast cell) ( 1 ) , HEK293T (epithelial) ( 2 ) , MDA-MB-231 (breast cell) ( 1 )

Downstream Regulation
Effects of modification on LRP6:	molecular association, regulation ( 2 )
Effects of modification on biological processes:	carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , signaling pathway regulation ( 1 ) , transcription, induced ( 1 )
Inhibit interaction with:	axin 1 (human) ( 2 )

References
1	Rong Z, et al. (2022) SIK2 maintains breast cancer stemness by phosphorylating LRP6 and activating Wnt/β-catenin signaling. Oncogene 35277657 Curated Info
2	Swiatek W, et al. (2006) Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation. J Biol Chem 281, 12233-41 16513652 Curated Info