Lys266
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Home > Acetylation Site Page: > Lys266  -  ATIC (human)

Site Information
IPAAAsFkHVsPAGA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 33363151
Available spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , non-small cell lung cancer ( 3 )
Relevant cell line - cell type - tissue:
HCT116 (intestinal) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 2 ) , NCI-H3255 (pulmonary) ( 3 ) , RKO (intestinal) ( 1 )

Upstream Regulation
Regulatory protein:
p53 (human) ( 1 )

Downstream Regulation
Effects of modification on ATIC:
enzymatic activity, inhibited ( 1 ) , protein degradation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 )

References 

1

Zhao J, et al. (2023) p53 promotes peroxisomal fatty acid β-oxidation to repress purine biosynthesis and mediate tumor suppression. Cell Death Dis 14, 87
36750554   Curated Info

2

Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51
23954790   Curated Info

3

Rikova K (2012) CST Curation Set: 16031; Year: 2012; Biosample/Treatment: cell line, H3255/iressa; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK
Curated Info

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