Lys53
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Home > Acetylation Site Page: > Lys53  -  PBEF (mouse)

Site Information
NSKVRKVkYEETVFY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 33351372

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 1 ) , 293 (epithelial) ( 1 ) , adipocyte ( 1 ) , HIB-1B (adipocyte) ( 1 ) , liver ( 2 )

Upstream Regulation
Treatments:
fasting ( 1 ) , nicotinamide ( 1 ) , trichostatin_A ( 1 )

Downstream Regulation
Effects of modification on PBEF:
enzymatic activity, inhibited ( 1 )

References 

1

Yoon MJ, et al. (2015) SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD(+) and Function in Mice. Cell Metab 21, 706-17
25921090   Curated Info

2

Weinert BT, et al. (2013) Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep 4, 842-51
23954790   Curated Info