Ser196
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Home > Phosphorylation Site Page: > Ser196  -  XPA (human)

Site Information
RSLEVWGsQEALEEA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 460698

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 7 ) , immunoprecipitation ( 3 , 5 ) , mass spectrometry ( 4 , 5 , 6 ) , mutation of modification site ( 3 , 5 , 7 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 3 )
Disease tissue studied:
lung cancer ( 3 , 7 ) , non-small cell lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 3 ) , testicular cancer ( 1 ) , Xeroderma pigmentosum ( 5 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ATR (human) ( 3 , 5 , 7 )
Kinases, in vitro:
ATM (human) ( 7 ) , ATR (human) ( 7 ) , DNAPK (human) ( 7 )
Treatments:
caffeine ( 7 ) , cisplatin ( 1 ) , UV ( 7 ) , wortmannin ( 7 )

Downstream Regulation
Effects of modification on XPA:
molecular association, regulation ( 3 ) , protein stabilization ( 3 )
Effects of modification on biological processes:
apoptosis, altered ( 7 ) , DNA repair, induced ( 3 )
Induce interaction with:
DNA ( 3 ) , H2AX (human) ( 3 ) , RPA1 (human) ( 3 )
Inhibit interaction with:
HERC2 (human) ( 3 )

References 

1

Cierna Z, et al. (2020) Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours. BMC Cancer 20, 17
31906898   Curated Info

2

Jarrett SG, et al. (2018) Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV damage. J Biol Chem
30327428   Curated Info

3

Lee TH, Park JM, Leem SH, Kang TH (2014) Coordinated regulation of XPA stability by ATR and HERC2 during nucleotide excision repair. Oncogene 33, 19-25
23178497   Curated Info

4

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

5

Shell SM, et al. (2009) Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A. J Biol Chem 284, 24213-22
19586908   Curated Info

6

Matsuoka S, et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-6
17525332   Curated Info

7

Wu X, Shell SM, Yang Z, Zou Y (2006) Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation. Cancer Res 66, 2997-3005
16540648   Curated Info