Ser76
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Home > Phosphorylation Site Page: > Ser76  -  PKD2 (human)

Site Information
AGAAASPsPPLSSCS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 460685

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 )
Disease tissue studied:
melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
GSK3A (human) ( 3 )
Kinases, in vitro:
GSK3A (human) ( 3 )
Treatments:
indirubin ( 3 ) , lithium ( 3 ) , SB216763 ( 3 ) , SB415286 ( 3 )

Downstream Regulation
Effects of modification on PKD2:
intracellular localization ( 3 )

References 

1

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

2

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

3

Streets AJ, et al. (2006) Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro. Hum Mol Genet 15, 1465-73
16551655   Curated Info