Tyr759
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Home > Phosphorylation Site Page: > Tyr759  -  gp130 (human)

Site Information
NTSSTVQyStVVHsG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448181
Associated spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 , 4 , 5 ) , mutation of modification site ( 2 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ) , phospho-antibody ( 1 , 8 ) , western blotting ( 1 , 8 )
Disease tissue studied:
gastric cancer ( 5 ) , liver cancer ( 6 , 8 , 11 ) , lung cancer ( 1 , 3 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 ) , non-small cell squamous cell lung carcinoma ( 3 ) , neuroblastoma ( 10 )
Relevant cell line - cell type - tissue:
'brain, embryonic' ( 12 ) , 293 (epithelial) ( 13 ) , A549 (pulmonary) ( 1 ) , BaF3 ('B lymphocyte, precursor') ( 7 ) , COS (fibroblast) ( 7 , 8 , 10 , 11 ) , HEK293T (epithelial) ( 2 , 9 ) , hepatocyte-liver ( 12 ) , HepG2 (hepatic) ( 6 , 7 , 8 , 11 ) , Hs746T (pancreatic) ( 5 ) , lymphocyte-spleen ( 12 ) , NCI-H1703 (squamous) ( 3 , 4 ) , SN56 (neuron) ( 10 )

Upstream Regulation
Regulatory protein:
CLCF1 (human) ( 1 )
Treatments:
IL-6 ( 11 )

Downstream Regulation
Effects of modification on gp130:
activity, induced ( 12 ) , activity, inhibited ( 7 , 8 , 11 ) , molecular association, regulation ( 6 , 7 , 9 , 11 , 13 ) , phosphorylation ( 2 , 10 , 11 )
Effects of modification on biological processes:
cell differentiation, altered ( 12 ) , signaling pathway regulation ( 2 ) , transcription, altered ( 6 , 7 , 10 , 11 )
Induce interaction with:
SHP-2 (human) ( 7 , 11 , 13 ) , SOCS3 (human) ( 6 , 9 , 11 )

References 

1

Kim JW, et al. (2020) Engineering a potent receptor superagonist or antagonist from a novel IL-6 family cytokine ligand. Proc Natl Acad Sci U S A
32522868   Curated Info

2

Cousins E, Gao Y, Sandford G, Nicholas J (2014) Human Herpesvirus 8 Viral Interleukin-6 Signaling through gp130 Promotes Virus Replication in Primary Effusion Lymphoma and Endothelial Cells. J Virol 88, 12167-72
25078695   Curated Info

3

Moritz A, et al. (2010) Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases. Sci Signal 3, ra64
20736484   Curated Info

4

Moritz A (2009) CST Curation Set: 5955; Year: 2009; Biosample/Treatment: cell line, NCI-H1703/Gleevec; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

5

Guo A (2006) CST Curation Set: 1937; Year: 2006; Biosample/Treatment: cell line, Hs746T/-; Disease: pancreatic carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

6

Stross C, et al. (2006) Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism. J Biol Chem 281, 8458-68
16459330   Curated Info

7

Anhuf D, et al. (2000) Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation. J Immunol 165, 2535-43
10946280   Curated Info

8

Terstegen L, et al. (2000) The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130. J Biol Chem 275, 18810-7
10764798   Curated Info

9

Nicholson SE, et al. (2000) Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc Natl Acad Sci U S A 97, 6493-8
10829066   Curated Info

10

Bartoe JL, Nathanson NM (2000) Differential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathways. J Neurochem 74, 2021-32
10800945   Curated Info

11

Schmitz J, et al. (2000) SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J Biol Chem 275, 12848-56
10777583   Curated Info

12

Ohtani T, et al. (2000) Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity 12, 95-105
10661409   Curated Info

13

Takahashi-Tezuka M, et al. (1998) Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase. Mol Cell Biol 18, 4109-17
9632795   Curated Info

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