Ser538
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Home > Phosphorylation Site Page: > Ser538  -  Artemis (human)

Site Information
HISsQNSsQSTHITE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 460662

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
ATM (human) ( 1 ) , ATR (human) ( 1 ) , DNAPK (human) ( 1 )
Kinases, in vitro:
DNAPK (human) ( 2 )
Treatments:
caffeine ( 1 ) , ionizing_radiation ( 1 ) , siRNA ( 1 ) , wortmannin ( 1 )

References 

1

Geng L, Zhang X, Zheng S, Legerski RJ (2007) Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B. Mol Cell Biol 27, 2625-35
17242184   Curated Info

2

Soubeyrand S, et al. (2006) Artemis phosphorylated by DNA-dependent protein kinase associates preferentially with discrete regions of chromatin. J Mol Biol 358, 1200-11
16600297   Curated Info