Thr444
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Home > Phosphorylation Site Page: > Thr444  -  NDR1 (mouse)

Site Information
DWVFINytYKRFEGL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 460659

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
leukemia ( 2 ) , T cell leukemia ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , brain ( 1 ) , D1 (T lymphocyte) ( 2 ) , embryo ( 1 ) , liver ( 1 )

Upstream Regulation
Regulatory protein:
MICAL1 (mouse) ( 2 ) , MST1 (mouse) ( 2 )
Treatments:
etoposide ( 2 ) , okadaic_acid ( 2 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on NDR1:
enzymatic activity, induced ( 2 )
Effects of modification on biological processes:
apoptosis, induced ( 2 ) , signaling pathway regulation ( 2 )

References 

1

Stokes MP, et al. (2012) PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS. Mol Cell Proteomics 11, 187-201
22322096   Curated Info

2

Zhou Y, et al. (2011) MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis. Mol Cell Biol 31, 3603-15
21730291   Curated Info