Ser692
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Home > Phosphorylation Site Page: > Ser692  -  eplin (mouse)

Site Information
NHVHAQQsPLEPEAP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 460654

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 3 ) , immunoassay ( 3 ) , immunoprecipitation ( 3 ) , mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 3 )
Kinases, in vitro:
ERK1 (human) ( 3 )
Treatments:
4-HT ( 3 ) , CIAP ( 3 ) , U0126 ( 3 )

Downstream Regulation
Effects of modification on eplin:
molecular association, regulation ( 3 )
Effects of modification on biological processes:
cell motility, induced ( 3 ) , cytoskeletal reorganization ( 3 )
Inhibit interaction with:
ACTB (human) ( 3 )

References 

1

Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83
23140645   Curated Info

2

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

3

Han MY, Kosako H, Watanabe T, Hattori S (2007) Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Regulates Actin Organization and Cell Motility by Phosphorylating the Actin Cross-Linking Protein EPLIN. Mol Cell Biol 27, 8190-8204
17875928   Curated Info