Ser60
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Home > Phosphorylation Site Page: > Ser60  -  CDX2 (mouse)

Site Information
ANLDSAQsPGPSWPT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 460651

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
colorectal cancer ( 3 ) , colorectal carcinoma ( 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , Caco-2 (intestinal) ( 3 ) , Caco-2/15 ( 2 ) , embryonic ( 1 ) , IEC-6 (epithelial) ( 2 ) , intestine ( 3 )

Upstream Regulation
Regulatory protein:
ERK1 (human) ( 2 ) , MEK1 (human) ( 2 )
Treatments:
acadesine ( 1 ) , PD98059 ( 2 , 3 ) , sorbitol ( 1 ) , U0126 ( 1 , 3 )

Downstream Regulation
Effects of modification on biological processes:
transcription, inhibited ( 2 , 3 )

References 

1

Xie Y, et al. (2013) Stress induces AMP-dependent loss of potency factors Id2 and Cdx2 in early embryos and stem cells. Stem Cells Dev 22, 1564-75
23316940   Curated Info

2

Lemieux E, et al. (2011) Constitutive activation of the MEK/ERK pathway inhibits intestinal epithelial cell differentiation. Am J Physiol Gastrointest Liver Physiol 301, G719-30
21737780   Curated Info

3

Rings EH, et al. (2001) Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity. Gastroenterology 121, 1437-50
11729123   Curated Info

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