Thr72
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Home > Phosphorylation Site Page: > Thr72  -  Akt1 (human)

Site Information
tERPRPNtFIIRCLQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 460648
Available spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mass spectrometry ( 2 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 , 3 )
Disease tissue studied:
lung cancer ( 2 ) , small-cell lung cancer ( 2 ) , pancreatic cancer ( 1 )
Relevant cell line - cell type - tissue:
DMS79 (pulmonary) ( 2 ) , lung ( 2 ) , MCF-7 (breast cell) ( 3 ) , NCI-H128 (pulmonary) ( 2 ) , NCI-H1417 (pulmonary) ( 2 ) , NCI-H209 (pulmonary) ( 2 ) , NCI-H524 (pulmonary) ( 2 ) , PC-1 (pancreatic) ( 1 ) , PC1.0 (pancreatic) ( 1 )

Upstream Regulation
Kinases, in vitro:
Akt1 (human) ( 3 )

Downstream Regulation
Effects of modification on Akt1:
enzymatic activity, induced ( 3 )
Effects of modification on biological processes:
apoptosis, inhibited ( 3 )

References 

1

Tan X, et al. (2016) Phosphoproteome Analysis of Invasion and Metastasis-Related Factors in Pancreatic Cancer Cells. PLoS One 11, e0152280
27014871   Curated Info

2

Rikova K, Hall B (2013) CST Curation Set: 20734, 21161, 30112, 30153, 30154; Year: 2013; Biosample/Treatment: cell line, H1417, DMS79, H128, H209, H524; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
Curated Info

3

Li X, et al. (2006) Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity. J Biol Chem 281, 13837-43
16549426   Curated Info