Lys274

Site Information
GRRSWARkRQAAHTC SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 460630

In vivo Characterization
Methods used to characterize site in vivo:	3H acetate labeling ( 2 ) , immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	leukemia ( 1 ) , chronic myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:	COS7 (fibroblast) ( 1 , 2 ) , K562 (erythroid) ( 1 ) , MEL (erythroid) ( 1 )

Downstream Regulation
Effects of modification on KLF1:	activity, induced ( 1 , 2 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:	transcription, induced ( 1 , 2 )

References
1	Zhang W, Kadam S, Emerson BM, Bieker JJ (2001) Site-specific acetylation by p300 or CREB binding protein regulates erythroid Krüppel-like factor transcriptional activity via its interaction with the SWI-SNF complex. Mol Cell Biol 21, 2413-22 11259590 Curated Info
2	Zhang W, Bieker JJ (1998) Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc Natl Acad Sci U S A 95, 9855-60 9707565 Curated Info