Lys40

Site Information
DGQMPsDktIGGGDD SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 460619

In vivo Characterization
Methods used to characterize site in vivo:	amino acid analysis ( 13 ) , flow cytometry ( 10 ) , immunoassay ( 16 , 17 , 21 , 23 , 24 , 25 , 29 , 30 , 33 , 34 , 35 , 37 , 38 , 39 , 44 , 51 , 65 , 66 ) , immunoprecipitation ( 2 , 5 , 6 , 7 , 9 , 10 , 11 , 29 , 42 , 44 , 50 ) , mass spectrometry ( 12 , 52 , 55 , 56 , 57 , 58 , 59 , 60 , 62 , 63 , 64 ) , mass spectrometry (in vitro) ( 13 ) , microscopy-colocalization with upstream kinase ( 13 ) , modification-specific antibody ( 1 , 3 , 4 , 5 , 7 , 9 , 12 , 14 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 28 , 29 , 30 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 40 , 41 , 42 , 45 , 47 , 48 , 49 , 51 , 54 , 65 ) , mutation of modification site ( 1 , 5 , 10 , 13 , 33 , 39 , 41 , 44 , 46 , 50 , 54 , 61 ) , phospho-antibody ( 15 , 16 , 17 , 42 , 43 ) , western blotting ( 1 , 2 , 4 , 5 , 6 , 7 , 9 , 10 , 11 , 12 , 13 , 15 , 19 , 20 , 21 , 22 , 24 , 25 , 28 , 29 , 32 , 33 , 34 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 47 , 48 , 49 , 50 , 51 , 54 , 65 , 66 )
Disease tissue studied:	bladder cancer ( 22 ) , bone cancer ( 3 , 7 , 10 , 29 , 50 ) , brain cancer ( 42 ) , medulloblastoma ( 42 ) , breast cancer ( 2 , 19 , 32 , 39 , 49 ) , cervical cancer ( 37 ) , cervical adenocarcinoma ( 37 ) , colorectal cancer ( 4 , 10 , 15 , 17 , 29 , 33 , 52 , 54 ) , colorectal carcinoma ( 4 , 10 , 15 , 17 , 29 , 33 , 52 , 54 ) , kidney cancer ( 4 ) , leukemia ( 21 ) , T cell leukemia ( 21 ) , lung cancer ( 38 , 39 , 55 , 66 ) , non-small cell lung cancer ( 38 , 39 , 66 ) , non-small cell lung adenocarcinoma ( 38 , 39 , 66 ) , lymphoma ( 19 ) , neuroblastoma ( 5 , 24 , 54 ) , ovarian cancer ( 16 , 32 ) , melanoma skin cancer ( 49 ) , fibrosarcoma of soft tissue ( 39 )
Relevant cell line - cell type - tissue:	'brain, cerebral cortex' ( 24 ) , 'neuron, cortical'-brain ( 53 ) , 'renal, podocyte' ( 9 ) , 'stem, embryonic' ( 65 ) , 16HBE (epithelial) ( 6 ) , 293 (epithelial) ( 4 , 5 , 11 , 44 , 54 ) , 3T3 (fibroblast) ( 3 , 6 , 65 , 66 ) , 786-O (renal) ( 4 ) , A2780 (ovarian) ( 32 ) , A549 (pulmonary) ( 38 , 39 , 55 , 66 ) , B16F0 (melanocyte) ( 49 ) , C2C12 (myoblast) ( 39 ) , C3H10T1/2 (fibroblast) ( 39 ) , Caco-2 (intestinal) ( 17 ) , CAD (neuron) ( 61 ) , CHO-K1 (fibroblast) ( 51 ) , COS (fibroblast) ( 61 ) , COS7 (fibroblast) ( 3 ) , Daoy ( 42 ) , E.coli (bacterial) ( 41 ) , ECV304 (endothelial) ( 21 ) , HaCaT (keratinocyte) ( 39 ) , HCT116 (intestinal) ( 10 , 15 , 29 , 33 , 52 , 62 ) , HEK293T (epithelial) ( 8 , 13 , 28 , 36 , 39 , 65 ) , HeLa (cervical) ( 7 , 10 , 20 , 25 , 29 , 30 , 34 , 35 , 37 , 46 , 48 , 50 , 51 , 61 ) , HeLa S3 (cervical) ( 37 ) , HT-29 (intestinal) ( 54 ) , hTERT-HME1 (epithelial) ( 39 ) , Jurkat (T lymphocyte) ( 21 ) , K562 (erythroid) ( 60 ) , L929 (fibroblast) ( 39 ) , LCSC (pulmonary) ( 38 ) , MCF-10A (breast cell) ( 39 ) , MCF-7 (breast cell) ( 19 ) , MDA-MB-231 (breast cell) ( 2 , 32 , 49 ) , MDCK (epithelial) ( 41 ) , MEF (fibroblast) [LRRK2 (mouse), homozygous knockout] ( 43 ) , MEF (fibroblast) ( 25 , 36 ) , MGC-803 (gastric) ( 40 ) , mononuclear-blood ( 7 ) , MRC5 (fibroblast) ( 3 ) , NCI-H1299 (pulmonary) ( 38 ) , ND7/23 ('neuron, dorsal root ganglion') ( 5 ) , Neuro-2a (neuron) ( 5 ) , neuron ( 14 , 45 , 54 ) , neuron-'brain, cerebral cortex' ( 5 ) , neuron-'brain, hippocampus' ( 5 , 24 , 61 ) , NHDF (fibroblast) ( 1 , 8 ) , NMuMG (epithelial) ( 39 ) , NSC34 (neuron) ( 44 ) , NSCLC (pulmonary) ( 38 ) , oligodendrocyte ( 51 ) , oocyte ( 12 ) , ovarian ( 16 ) , RKO (intestinal) ( 4 ) , RPE-1 (retinal) ( 21 ) , RT112 (bladder cell) ( 22 ) , sciatic nerve ( 23 ) , SH-SY5Y (neural crest) ( 24 , 54 ) , SK-N-BE(2) (neural crest) ( 54 ) , SKOV-3 (ovarian) ( 16 ) , SW480 (intestinal) ( 15 ) , SW620 (intestinal) ( 63 , 64 ) , T lymphocyte ( 47 ) , U-937 (myeloid) ( 19 ) , U2OS (bone cell) ( 3 , 7 , 10 , 29 , 50 ) , UOK-101 (renal) ( 58 , 59 )

Upstream Regulation
Regulatory protein:	AML3 (human) ( 2 ) , ATAT1 (human) ( 10 , 21 , 45 ) , ATM (human) ( 10 ) , ATR (human) ( 10 ) , BCCIP (human) ( 25 ) , BRCA1 (human) ( 10 ) , CAMSAP3 (human) ( 17 ) , Diaphanous-1 (human) ( 21 ) , GRK2 (human) ( 46 ) , INF2 (human) ( 21 ) , MAP2 (human) ( 37 ) , MKL1 (human) ( 21 ) , Moesin (human) ( 4 ) , NAA50 (human) ( 48 ) , NQO1 (human) ( 6 ) , RITA1 (human) ( 29 ) , SIRT2 (human) ( 6 ) , TMIGD1 (human) ( 4 ) , TPPP (human) ( 51 )
Treatments:	A769662 ( 34 ) , ACY-241 ( 32 ) , AGK2 ( 15 , 37 ) , AK1 ( 24 ) , butyrate ( 47 ) , CEU ( 49 ) , cisplatin ( 16 ) , colchicine ( 49 ) , CPT ( 10 ) , CPTH6 ( 38 ) , cytochalasin_D ( 21 ) , DEM ( 34 ) , differentiation ( 38 ) , doxycycline ( 51 ) , EGF ( 42 , 55 ) , eribulin ( 23 ) , FK866 ( 37 ) , fosbretabulin ( 49 ) , H2O2 ( 20 ) , hydroxyurea ( 10 ) , hypertonic_buffer ( 37 , 42 ) , injury ( 14 ) , low Na ( 42 ) , MC2494 ( 19 ) , MI2321 ( 6 ) , NaB ( 65 , 66 ) , nicotinic_acid ( 37 ) , NMN ( 6 ) , nocodazole ( 35 ) , SB431542 ( 39 ) , siRNA ( 10 , 37 , 39 , 44 ) , taxol ( 21 , 23 , 32 , 37 , 49 , 66 ) , TGF-beta ( 39 ) , TPXb ( 65 , 66 ) , trichostatin_A ( 3 , 36 , 37 , 46 , 47 , 51 , 65 , 66 ) , tubacin ( 21 , 29 , 37 ) , vinblastine ( 49 )

Upstream Regulation

Regulatory protein:

AML3 (human) ( 2 ) , ATAT1 (human) ( 10 , 21 , 45 ) , ATM (human) ( 10 ) , ATR (human) ( 10 ) , BCCIP (human) ( 25 ) , BRCA1 (human) ( 10 ) , CAMSAP3 (human) ( 17 ) , Diaphanous-1 (human) ( 21 ) , GRK2 (human) ( 46 ) , INF2 (human) ( 21 ) , MAP2 (human) ( 37 ) , MKL1 (human) ( 21 ) , Moesin (human) ( 4 ) , NAA50 (human) ( 48 ) , NQO1 (human) ( 6 ) , RITA1 (human) ( 29 ) , SIRT2 (human) ( 6 ) , TMIGD1 (human) ( 4 ) , TPPP (human) ( 51 )

Treatments:

A769662 ( 34 ) , ACY-241 ( 32 ) , AGK2 ( 15 , 37 ) , AK1 ( 24 ) , butyrate ( 47 ) , CEU ( 49 ) , cisplatin ( 16 ) , colchicine ( 49 ) , CPT ( 10 ) , CPTH6 ( 38 ) , cytochalasin_D ( 21 ) , DEM ( 34 ) , differentiation ( 38 ) , doxycycline ( 51 ) , EGF ( 42 , 55 ) , eribulin ( 23 ) , FK866 ( 37 ) , fosbretabulin ( 49 ) , H2O2 ( 20 ) , hydroxyurea ( 10 ) , hypertonic_buffer ( 37 , 42 ) , injury ( 14 ) , low Na ( 42 ) , MC2494 ( 19 ) , MI2321 ( 6 ) , NaB ( 65 , 66 ) , nicotinic_acid ( 37 ) , NMN ( 6 ) , nocodazole ( 35 ) , SB431542 ( 39 ) , siRNA ( 10 , 37 , 39 , 44 ) , taxol ( 21 , 23 , 32 , 37 , 49 , 66 ) , TGF-beta ( 39 ) , TPXb ( 65 , 66 ) , trichostatin_A ( 3 , 36 , 37 , 46 , 47 , 51 , 65 , 66 ) , tubacin ( 21 , 29 , 37 ) , vinblastine ( 49 )

Downstream Regulation
Effects of modification on TUBA1A:	acetylation ( 3 , 4 , 43 ) , activity, induced ( 1 ) , intracellular localization ( 33 , 61 ) , molecular association, regulation ( 47 , 61 ) , phosphorylation ( 50 ) , protein stabilization ( 2 , 7 , 11 , 14 , 49 )
Effects of modification on biological processes:	apoptosis, inhibited ( 38 ) , autophagy, induced ( 2 , 9 , 24 , 50 ) , carcinogenesis, induced ( 33 , 38 ) , cell adhesion, inhibited ( 46 ) , cell cycle regulation ( 10 , 11 , 29 ) , cell differentiation, induced ( 51 , 54 ) , cell growth, induced ( 11 , 38 ) , cell motility, altered ( 1 , 4 , 51 ) , cell motility, induced ( 53 , 54 ) , cell motility, inhibited ( 9 , 39 , 46 , 66 ) , cytoskeletal reorganization ( 2 , 4 , 8 , 17 , 24 , 25 , 29 , 34 , 36 , 37 , 39 , 42 , 44 , 45 , 46 , 49 , 50 , 51 , 65 , 66 ) , DNA repair, induced ( 10 ) , signaling pathway regulation ( 1 , 33 ) , transcription, induced ( 33 )
Induce interaction with:	KIF5B (human) ( 61 )
Inhibit interaction with:	LRRK2 (human) ( 43 ) , NFAT1 (human) ( 47 )

Disease / Diagnostics Relevance
Relevant diseases:	Alzheimer's disease ( 24 )

References
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52	Moritz A (2010) CST Curation Set: 9796; Year: 2010; Biosample/Treatment: cell line, HCT 116/untreated; Disease: colorectal carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Curated Info
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56	Rikova K (2007) CST Curation Set: 3512; Year: 2007; Biosample/Treatment: cell line, 786-0 vector/untreated; Disease: kidney cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine (Ac-K2-100) Rabbit mAb Cat#: 9814, PTMScan(R) Acetyl-Lys Motif (Ac-K) Immunoaffinity Beads Cat#: 1989 Curated Info
57	Rikova K (2007) CST Curation Set: 3514; Year: 2007; Biosample/Treatment: cell line, 786-0 VHL-30/untreated; Disease: kidney cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine (Ac-K2-100) Rabbit mAb Cat#: 9814, PTMScan(R) Acetyl-Lys Motif (Ac-K) Immunoaffinity Beads Cat#: 1989 Curated Info
58	Rikova K (2007) CST Curation Set: 3516; Year: 2007; Biosample/Treatment: cell line, UOK-101/untreated; Disease: kidney cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine (Ac-K2-100) Rabbit mAb Cat#: 9814, PTMScan(R) Acetyl-Lys Motif (Ac-K) Immunoaffinity Beads Cat#: 1989 Curated Info
59	Rikova K (2007) CST Curation Set: 3518; Year: 2007; Biosample/Treatment: cell line, UOK-101/untreated; Disease: kidney cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine (Ac-K2-100) Rabbit mAb Cat#: 9814, PTMScan(R) Acetyl-Lys Motif (Ac-K) Immunoaffinity Beads Cat#: 1989 Curated Info
60	Possemato A (2007) CST Curation Set: 2735; Year: 2007; Biosample/Treatment: cell line, K562/untreated; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine (Ac-K2-100) Rabbit mAb Cat#: 9814, PTMScan(R) Acetyl-Lys Motif (Ac-K) Immunoaffinity Beads Cat#: 1989 Curated Info
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62	Li Y (2006) CST Curation Set: 1295; Year: 2006; Biosample/Treatment: cell line, HCT116/TSA; Disease: colorectal carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine Antibody Cat#: 9441 Curated Info
63	Li Y (2006) CST Curation Set: 1296; Year: 2006; Biosample/Treatment: cell line, SW620/untreated; Disease: colorectal carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine Antibody Cat#: 9441 Curated Info
64	Li Y (2006) CST Curation Set: 1297; Year: 2006; Biosample/Treatment: cell line, SW620/TSA; Disease: colorectal carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: acK Antibodies Used to Purify Peptides prior to LCMS: Acetylated-Lysine Antibody Cat#: 9441 Curated Info
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