Thr178
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Home > Phosphorylation Site Page: > Thr178  -  TAK1 (human)

Site Information
LKICDFGtACDIQtH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3303400

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 1 ) , HEK293T (epithelial) ( 2 ) , MEF (fibroblast) ( 2 )

Upstream Regulation
Putative in vivo kinases:
TAK1 (human) ( 1 )
Treatments:
IL-1b ( 2 )

Downstream Regulation
Effects of modification on TAK1:
enzymatic activity, induced ( 1 , 2 ) , phosphorylation ( 1 , 2 )

References 

1

Scholz R, et al. (2010) Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process. J Biol Chem 285, 25753-66
20538596   Curated Info

2

Yu Y, et al. (2008) Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression. J Biol Chem 283, 24497-505
18617512   Curated Info