Thr47
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Home > Phosphorylation Site Page: > Thr47  -  Bcl-xL (human)

Site Information
GTESEMEtPsAINGN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448163

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mutation of modification site ( 2 , 3 , 4 ) , peptide sequencing ( 3 ) , phospho-antibody ( 1 ) , phosphoamino acid analysis ( 4 ) , phosphopeptide mapping ( 4 ) , western blotting ( 2 , 3 )
Disease tissue studied:
lymphoma ( 2 ) , Burkitt's lymphoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
JNK1 (human) ( 4 )
Kinases, in vitro:
JNK2 (human) ( 4 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, altered ( 3 ) , apoptosis, induced ( 4 ) , cell cycle regulation ( 3 )
Inhibit interaction with:
CDK1 (human) ( 3 )

References 

1

Han KH, et al. (2017) Protein profiling and angiogenic effect of hypoxia-cultured human umbilical cord blood-derived mesenchymal stem cells in hindlimb ischemia. Tissue Cell 49, 680-690
28958480   Curated Info

2

Wang J, Beauchemin M, Bertrand R (2012) Phospho-Bcl-x(L)(Ser62) plays a key role at DNA damage-induced G(2) checkpoint. Cell Cycle 11, 2159-69
22617334   Curated Info

3

Schmitt E, Beauchemin M, Bertrand R (2007) Nuclear colocalization and interaction between bcl-xL and cdk1(cdc2) during G2/M cell-cycle checkpoint. Oncogene 26, 5851-65
17369848   Curated Info

4

Kharbanda S, et al. (2000) Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem 275, 322-7
10617621   Curated Info