Ser4629

Site Information
ysVsGsGstAGsrtG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 459951

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 )
Disease tissue studied:	anthrax infection ( 8 ) , neuroblastoma ( 7 )
Relevant cell line - cell type - tissue:	'3T3-L1, differentiated' (adipocyte) ( 4 ) , 'fat, brown' ( 9 ) , brain ( 9 ) , heart ( 9 ) , Hepa 1-6 (epithelial) ( 10 ) , kidney ( 9 ) , liver ( 3 , 5 , 9 ) , liver [leptin (mouse), homozygous knockout] ( 5 ) , lung ( 9 ) , MC3T3-E1 (preosteoblast) ( 1 ) , MEF (fibroblast) [TSC2 (mouse), homozygous knockout] ( 6 ) , N1E-115 (neuron) ( 7 ) , pancreas ( 9 ) , RAW 264.7 (macrophage) ( 2 ) , spleen ( 8 , 9 ) , testis ( 9 )

Upstream Regulation
Treatments:	insulin ( 4 ) , LPA ( 7 ) , LY294002 ( 4 ) , MK-2206 ( 4 ) , refeeding ( 5 )

References
1	Williams GR, et al. (2016) Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics. Methods 92, 36-50 26160508 Curated Info
2	Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44 25367039 Curated Info
3	Wilson-Grady JT, Haas W, Gygi SP (2013) Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods 61, 277-86 23567750 Curated Info
4	Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20 23684622 Curated Info
5	Grimsrud PA, et al. (2012) A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. Cell Metab 16, 672-83 23140645 Curated Info
6	Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6 21659605 Curated Info
7	Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201 21454597 Curated Info
8	Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927 21189417 Curated Info
9	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
10	Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46 18846507 Curated Info