Lys495
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Home > Acetylation Site Page: > Lys495  -  GR (human)

Site Information
LEARkTkkKIkGIQQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3287301

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , liver cancer ( 1 ) , lung cancer ( 2 ) , non-small cell lung cancer ( 2 ) , non-small cell lung adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:
'macrophage, alveolar' ( 2 ) , A549 (pulmonary) ( 2 ) , HCT116 (intestinal) ( 1 ) , HeLa (cervical) ( 1 ) , HepG2 (hepatic) ( 1 )

Upstream Regulation
Treatments:
dexamethasone ( 2 ) , siRNA ( 1 , 2 ) , trichostatin_A ( 2 )

Downstream Regulation
Effects of modification on GR:
molecular association, regulation ( 1 , 2 ) , receptor desensitization, induced ( 2 )
Effects of modification on biological processes:
transcription, induced ( 2 ) , transcription, inhibited ( 1 )
Inhibit interaction with:
DNA ( 1 ) , NFkB-p65 (human) ( 2 )

References 

1

Nader N, Chrousos GP, Kino T (2009) Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications. FASEB J 23, 1572-83
19141540   Curated Info

2

Ito K, et al. (2006) Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J Exp Med 203, 7-13
16380507   Curated Info